Impaired cytokine expression, neutrophil infiltration and bacterial clearance in response to urinary tract infection in diabetic mice
نویسندگان
چکیده
منابع مشابه
Advanced glycation end products facilitate bacterial adherence in urinary tract infection in diabetic mice.
Diabetic individuals have increased susceptibility to urinary tract infection (UTI), a common, painful condition. During diabetes mellitus, non-enzymatic reactions between reducing sugars and protein amine groups result in excessive production of advanced glycation end products (AGEs) that accumulate in tissues. Since bacteria adhere to cell surfaces by binding to carbohydrates, we hypothesized...
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BACKGROUND Exposure to microorganisms elicts the production of cytokines. These soluble factors enhance several innate immune functions and regulate the ensuing specific immune response aimed at limiting the spread of infection. AIM This study was undertaken to quantify the plasma levels of pro-inflammatory cytokines during the course of primary Listeria monocytogenes and Campylobacter jejuni...
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Neutropenia and neutrophil dysfunction are common in many diseases, although their etiology is often unclear. Previous views held that there was a single ER enzyme, glucose-6-phosphatase-alpha (G6Pase-alpha), whose activity--limited to the liver, kidney, and intestine--was solely responsible for the final stages of gluconeogenesis and glycogenolysis, in which glucose-6-phosphate (G6P) is hydrol...
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GUL, M., KURUTAS, E., CIRAGIL, P., CETINKAYA, A., KILINC, M., ARAL, M. and BUYUKBESE, M.A. Urinary Tract Infection Aggravates Oxidative Stress in Diabetic Patients. Tohoku J. Exp. Med., 2005, 206 (1), 1-6 ── To investigate the effect of urinary tract infection on oxidative stress in diabetic patients, we measured the activities of antioxidant enzymes such as catalase and superoxide dismutase, a...
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ژورنال
عنوان ژورنال: Pathogens and Disease
سال: 2015
ISSN: 2049-632X
DOI: 10.1093/femspd/ftv002